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KMID : 0605720070130010090
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Journal of the Korean Society of Biological Therapies in Psychiatry
2007 Volume.13 No. 1 p.90 ~ p.96
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Polymorphisms of G-protein β3 Subunit Gene(GNB3) C1429T in Korean Schizophrenic Patients
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Seo Hong-Seok
Lee Sun-Woo
Wang Seung-Keun
Chee Ik-Seung
Kim Jeong-Lan
Yoon Ji-Young
Lee Tea-Keong
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Abstract
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Objectives：This study aimed to investigate the association between polymorphisms of CNB3/C1429T and schizophrenia.
Methods：100patients with schizophrenia and 90controls were enrolled in the study. A polymerase chain reaction( PCR) with restriction fragment length enzyme(RFLP) was used to genotype the C1429T polymorphisms.
Results：1) In schizophrenic patients, genotype distributions of the GNB3/C1429T polymorphism were CC 64(64.0%), CT 36(36.0%) and TT 0(0.0%), and allele frequencies were C 164(82.0%), and T 36(18.0%). In normal control, genotype distributions of the GNB3/C1429T polymorphism were CC 60(66.7%), CT 24(26.7%) and TT 6(6.7%), and allele frequencies were C 144(80.0%), and T 36(20.0%). There were significant differences in the genotype frequencies of the GNB3/C1429T polymorphisms between the schizophrenia patients and the controls, while no significant differences in the alleic frequencies. 2) There were no difference in genotype distribution and allele frequencies of the GNB3/C1429T polymorphism, when patients were categorized by sex, family history of psychiatric disease, severity of symptom with PANSS scale.
Conclusions：These results suggest a GNB3/C1429T polymorphism is causally related to the pathogenesis of schizophrenia in the Korean population. Further study of GNB3/C1429T polymorphism should be needed, including family based association study and other clinical variations of schizophrenia.
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KEYWORD
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Schizophrenia, G-protein β3 subunit gene(GNB3), C1429T, Polymorphism
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